Category Archive: Science

Sep 12

“Will a tumour spread?”

The article “The Invasion Equation. Will a tumor spread? That may depend as much on your body as on your cancer” by Siddhartha Mukherjee in the New Yorker nicely explains metastasis or how tumour cells spread in the body.

Sep 09

What lessons have been learnt?

Today is the final day of the Third International Cancer lmmunotherapy Conference. The meeting was run at the Rheingoldhalle Congress Center in Mainz/Frankfurt, Germany from September 6-9, 2017. More than 500 people attended this meeting. The focus of the scientific program was on “Translating Science into Survival”. Talks covered the challenging areas in cancer immunology …

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Sep 08

Father of Chemotherapy and Cancer Immunology

I was giving a talk at Georg-Speyer-Haus Institute for Tumour Biology and Experimental Therapy yesterday. The aim of my visit was to establish collaboration with Prof Daniela Krause, who is the expert in bone marrow microenvironment and targeted therapies. She took me to the Institute museum that keeps the history of this place and phenomenal researchers …

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Sep 07

Tumour immunology and immunotherapy for neuroblastoma

The main challenge in treating high-risk neuroblastoma is to stop or control tumour spread and development of resistance to multiple chemotherapeutic drugs. Immunotherapy is one of the recent advances in our understanding how our immune system handles body invaders such as virosis, bacteria and now tumour cells. Immunotherapy holds great promise as a treatment option for neuroblastoma …

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Sep 06

Treatment of High-Risk Neuroblastoma

Children with high-risk neuroblastoma is the most challenging group to treat. Current treatment strategy for this group consists of 3 treatment blocks: induction: chemotherapy and primary tumour resection; consolidation: high-dose chemotherapy with autologous stem-cell rescue and external-beam radiotherapy [XRT]; post-consolidation: anti–ganglioside 2 immunotherapy with cytokines and cis-retinoic acid. Up to 50% of children that do respond experience disease recurrence with tumour resistant to …

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Sep 05

What is the risk group classification system?

To be able to guide the treatment of neuroblastoma patients, doctors have developed a number of classification systems. Although sharing common features, they slightly vary by medical center, country and continents making direct comparisons of treatment results difficult. Doctors and scientists are trying to consolidate all systems in one in order to evaluate treatments in …

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Sep 04

What is neuroblastoma?

Neuroblastoma is a childhood cancer. The word neuroblastoma consists of two words neuro and blastoma.The term neuro refers to nerves, blastoma  –  to a cancer of immature cells. It starts in some types of nerve cells during embryo development.transforming immature nerve cells into cancerous cells. This type of cancer occurs most often in infants and young …

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Sep 02

What is cancer?

Cancer is an umbrella term that covers a group of diseases sharing the common features but diseases vary by site of origin, tissue type, race, sex, and age. One of the main features is an uncontrollable growth of cells. These cells are capable of spreading to other parts of the body. This process is also known as …

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Sep 01

September is Childhood Cancer Awareness Month

September is Childhood Cancer Awareness Month! Facts about childhood cancer Please watch this video created by St. Baldrick’s Foundation | The Childhood Cancer Ripple Effect References: Gatta G, Botta L, Rossi S, Aareleid T, Bielska-Lasota M, Clavel J, et al. Childhood cancer survival in Europe 1999-2007: Results of EUROCARE-5-a population-based study. Lancet Oncol. 2014;15(1):35–47. Ward …

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Aug 11

SIOPEN Meeting 2017

The dates for the SIOPEN AGM and Neuroblastoma Research Symposium were announced. This meeting will be hosted by the German So­cie­ty for Pa­ed­ia­tric On­co­lo­gy and Hae­ma­to­lo­gy and will take place @ Langenbeck Virchow Haus, Berlin, Germany on October 25-27, 2017. Mission To increase the understanding of neuroblastoma pathogenesis, progression and treatment failure and to improve …

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