#LoveResearch – Page 5 – Blog about neuroblastoma research

Ellen here!

Ellen here! It has been a while (almost 3 years, actually) since my last blog post and a lot has happened in the meantime. Life as a first-year PhD student is very different to life as a third-year student. Even writing this blog post has really opened my eyes to how much I have grown and developed, both personally and professionally. Don’t get me wrong, the past three years have been a rollercoaster of ups and downs, but having a supportive supervisor and a great group of friends around me in the lab has made the journey a lot easier.

Everyone has their own “survival guide” for getting through a PhD, from daily walks in the fresh air to after-work downtime with friends. For me, taking “brain breaks” little and often has been my saving grace. I love to travel and experience new places and so, with a bit of planning and (a good bit of) saving, I have taken my “brain breaks” in a few new cities since starting my PhD. Seeing the world has always been a priority of mine, and I am very lucky that I have been able to keep this up during the last few years. Working hard and efficiently during the 9 to 5 makes taking a day or two off every-so-often possible.
Because I live in Ireland, I am fortunate to have most of Europe on my doorstep and thanks to Ryanair I can travel quite cheaply (we all know the miserable stipend saga). I have had a few travel firsts over the last few years with a few of these being trips to Spain. I travelled to Barcelona to visit Catherine, a fellow PhD student on secondment there. We visited Sagrada Familia and Parque Güell, some of Gaudi’s famous sites and made sure to take as many pictures as we could with all the pretty views.

More recently, I visited Seville and was blown away. It is almost like a mini-Barcelona, with all of the great food, rich history and ancient architecture that Barcelona has but with the added charm of being much smaller and walkable. It was so surprising to know most locals don’t speak English at all and you can really feel the sense of community and pride that the Sevillians have in their culture. I visited Seville in the middle of the famous orange blossom season, and it was amazing to walk the streets with the constant perfume of oranges. They are quite big, though, and they do fall, so you have to be ready to dodge them every now and again.

Outside of Spain, I visited Milan for the first time, and I finally understood why people love Aperol Spritz (it just took having a very authentic Italian one to convince me). I visited the Duomo cathedral and ate the most amazing pasta and pizza (Dominos will never live up to the standards now), and as the fashion capital of the world, I got to “window-shop” at all the VERY expensive designer shops. Milan, as a city, has a very luxurious and expensive feel to it. When in reality it is very affordable and only a short flight from Dublin. 10/10 would recommend for an easy PhD “brain break”.

If I had to choose my favourite city that I have visited so far, I think it would have to be Seville. But there are plenty of others that would give it a run for it’s money. Corfu, Vilamoura and Dubrovnik to name a few.

A PhD is a marathon, not a sprint! Taking a day or two off to see these parts of the world has been the best way for me to stay productive over the past 3 years. Most of us have spent the majority of our 20s in school or college and choosing to do a PhD adds another layer (and another 3 or 4 years) to that education. For me, it was important to come to the end of my 20s with a jam-packed thesis but also a jam-packed camera roll filled with my travel memories. At the end of the day, a PhD is not all-consuming and life must go on outside of the “lab bubble”. It is possible to do both and have a lot of fun along the way.

Written by Ellen King

My Irish Chapter

Moving to a new country could be a challenge, an opportunity, or perhaps both. It involves stepping outside of your comfort zone, but that is where growth happens.

The most exciting opportunity of 2022 was my joining Dr Olga’s Lab as an MSc student. Welcome to the Research world full of uncertainty! Each day comes with a fresh set of surprises! Which is not uncommon in a lab environment. Sometimes things do not turn out the way we plan. But I am confident that every surprise will be worth it. My project contributes to the big ambition of Dr Olga’s team to develop an anti-cancer vaccine for children with neuroblastoma. It spans one year, which is rather short, but it gives me a fair impression of what a PhD journey might look like. I am already two months in, setting up my experiments, troubleshooting protocols and learning new things daily. Nevertheless, I enjoy that our team is outgoing, and I am eternally thankful to the whole team for their tremendous support and making me feel like I belong.

**#Christmas party# enjoying every moment of this journey, before I miss the memories I am creating in Ireland.**

Outside of academics, I made a few adjustments. I got the chance to become acquainted with a new housing market, banking system, and visa administration as a non-Irish citizen. It seems simple, not really!

I also enjoy challenging my long-held beliefs. For instance, the after-work hangout and drinks is an intriguing example of a cultural difference I’ve noticed here. In Portugal, I used to enjoy my lab breaks with some pastel de nata with black coffee, but now I prefer a cup of butter h0t chocolate, which is everywhere.

Chinese New Year in Ireland

Hi, this is Lin, it’s my second year living in Dublin and the second Chinese New Year I celebrated here. I love Dublin not only because it is the country I’ve spent more time in than any other country besides China but also because it can support Chinese traditional culture to the greatest extent.

Spring Festival (Chinese New Year) is China’s biggest extravaganza. In 2023 we celebrated it on 22nd February. According to the Chinese calendar, the world enters the Year of the Rabbit. I felt the Chinese New Year everywhere in Dublin.

Chinese New Year’s Eve is an important night for Chinese families, like Christmas Eve for the Irish. I didn’t go back to China, but I was with my Chinese friends in Dublin and celebrated together on that day. We put up spring couples and paper cutouts in our apartment, ordered some traditional Chinese food, and made some dumplings. We stayed home, stayed up late, and said goodbye to the old year. We did every vital ritual as we did at home.

In town, people also celebrated the Chinese New Year. Most notably, Good World Chinese Restaurant, my favourite Chinese restaurant in Dublin, has always contributed greatly to promoting Chinese culture. They received the Chinese Intangible Culture Heritage title from UNESCO for having one of the most traditionally prepared dim sums. On the day of Chinese New Year, they had the lion dance and worshipped the Gods of wealth. They think these vital rituals can bring people luck and wealth.

My Irish friends said “Happy Chinese New Year” to me with warmth and friendliness on Chinese New Year. They respect not only Chinese New Year but also any Chinese culture. Their kindness makes me feel at home.

I love my friends, and I love everything in Dublin!

Written by Lin Ma (PhD student)

How are you, PI?

Yeah, our (my) blogging is sporadic. The pattern is well recognisable – more posts with success stories or accomplishments or about the key activities. It is easy to share :). Please excuse us (me) when we are off the radar, but we remember our supporters and readers. We are back on track to celebrate Childhood Cancer Awareness Month this September.

So, how did my summer go? Well, nothing to complain about. I had time to go back to the labs, pick up on the outstanding task, and take on the white coat. Indeed, it comes with some assurance as well as troubleshooting. Some days were better than others. Some experiments worked, and another was inconsistent or inconclusive.

A fancy photo, but the routine cell culture itself can be very boring.

Where did I pick it up? This research journey is one year old already. 🙂 This project is focused on validation our 3D neuroblastoma model to test novel therapeutics. We set an experiment that required different expertise and contribution from every team member. In an ideal world, it was supposed to finish in 6 months. But the reality doesn’t stop to shake you. Various components have been delayed sometimes due to unforeseen circumstances (e.g. a broken equipment or out of stock reagent) or due to the lack of manpower or miscommunication at a given time. Eventually, we put the work on hold in October 2021, when we completed ~60%. Another go to continue was taken in April 2022. No luck! Then plan B was activated, and I have been back in the labs. Despite these challenges, this time has not been lost. We developed new ideas to complement the original plan. Now, the crucial 20% has to be done and dusted within 2 weeks time before teaching starts. Wish us a luck!

After the challenge of leading the Foundation Year Medicine Cycle, I am 100% positive that I love research with all up and downs. This routine is fascinating, it is not static. One day differs from another. Research questions are flowing in non-stop…

Not quite all back to in-person – the EFEM student Symposium 2022

Despite our last blog post celebrating the regained opportunity to meet with other researchers in person and all the benefits that come with it I just had the pleasure of presenting at the first European Federation for Experimental Morphology (EFEM) Student Symposium online.

While it would have been easy for me to attend in person, as the event was hosted and organised here at RCSI, not many others would have had it quite so easy. As the name suggests, researchers from all across Europe attended. Every EFEM associated anatomical society across Europe and RCSI, as the host institution, had the opportunity to select two members to present. I was honoured to be chosen to represent RCSI. Overall, 15 different countries were represented in the student talks which made for a diverse mix that was particularly nice for the bit of organized fun at the end of the first day which encouraged networking.

Especially, because having only begun my PhD this past year I felt the category Preliminary Results and Outlook aimed at Undergrads, Masters and early-stage PhD students perfectly suited the stage of my project. This was also a brilliant way to see what other students at my level were doing in the field of anatomical research all across Europe. Having this chance to see research in progress was refreshing and uplifting contrasted with the usually more rounded later stage presentations. Having studied anatomy in my undergraduate degree I was also delighted to simply engage with more conventional anatomical research than I currently do myself.

*Ronja Struck, 1Yr PhD student at the EFEM Student Symposium 2022*

A wonderful opportunity to gain insights into, for example, the implicit knowledge of academia was the career development part of the conference. Talks about academia, industry and publishing offered a chance to get an inside view of those career paths at different positions within them. Especially the typical day in a research journal’s editor provided a new perspective on what is important when writing papers and will have lasting benefits for me and my scientific writing.

But by far the reason why I’ll remember this conference for the longest time is that being awarded runner up in the category Preliminary Results and Outlook reassured me that I am on the right track and that there is purpose in what I do. Despite the online format of the conference, I had the honour of receiving my prize in person, because Prof. Fabio Quondamatteo, the organiser of the event is based at RCSI.

Overall, the two days were an important step in consolidating my faith in my work and the career path that I have chosen.

Written by Ronja Struck, the IRC-CFNCRF funded PhD student

First Research Meeting For A Medical Student

At the beginning of my career, I worked for two years in a Ukrainian company organizing international industrial conferences. So I have insider knowledge of how the conference works, and that the determining factor for the success is the active communication between the participants. And at the RCSI research day and Cork IACR conference, this component was perfect. At both events, I presented my poster and had a chance to discuss the recent advances in neuroblastoma epigenetic drug research. During RCSI Research day, I was excited to learn about the accomplishments of other undergraduate studies and was thrilled to learn that my classmate is participating in research too. He had developed an online recourse to practice cardiac auscultation, which is extremely useful for my medical studies. But professionally, I enjoyed the cancer research posters and presentations at the IACR conference and was eager to meet the researchers working on medulloblastoma, a paediatric neural cell cancer, and the research team from UCD, the neighbours of our university who worked on breast cancer. It was the most valuable opportunity to take a glimpse into other research, become inspired by the most ingenious methods, and cultivate professional knowledge and personal connections – I am so lucky I have been at RCSI Research day and the IACR conference! I have greatly enjoyed my time, and I am looking forward to (hopefully) going to the next year’s conferences again.

Written by Nadiya Bayeva