From Lab to Life: How Research Turns into Real Impact

When people think about scientific research, they often imagine complex equipment, long experiments, and data that only scientists understand. But behind every lab experiment lies a bigger purpose: improving real lives.

As a pharmacy student at RCSI University of Medicine and Health Sciences, I experienced this connection firsthand. During my studies, I carried out research in the RCSI Cancer Bioengineering Lab as part of my thesis work. This gave me the opportunity to see how laboratory science can contribute to real advances in healthcare.

Starting in the Lab

My project focused on developing new materials that could support therapeutic cancer vaccines (adjuvants). These vaccines are different from traditional ones because, instead of preventing disease, they are designed to help the body fight cancer more effectively.

At the centre of this research is alginate, a natural material derived from brown algae. Although simple in origin, it can be modified into tiny gel-like particles with immune-stimulating potential.

In the lab, this involved preparing solutions, carefully mixing components, and analysing the particles using techniques such as DLS and NTA. Small changes in concentration or preparation could completely alter the outcome, which required patience, precision, and problem-solving.

More Than Just Experiments

At first, lab work can feel like simply following steps: weighing chemicals, stirring solutions, and running instruments. But over time, I began to understand the bigger picture. This is where research becomes meaningful — each small experiment contributes to the larger goal of developing life-changing therapeutics.

Challenges Along the Way

Research is not always straightforward. Not every experiment works as expected. Sometimes results are unclear, and methods need to be adjusted and repeated.

During my project, I had to optimise various conditions to achieve stable, effective particles while also reviewing previous studies in this field. This involved testing multiple concentrations and analysing their behaviour. It taught me that failure is not a setback, but an essential part of discovery.

Connecting to Real Life

The most important lesson I learned is that research is never just about the lab.

The materials we develop could one day be used to enhance cancer treatments, improving patient outcomes and quality of life. While my work is still in its early stages, it contributes to a broader effort to make therapies more effective and targeted.

As a future pharmacist, this connection is especially important. It highlights how science, healthcare, and patient care are all deeply linked.

From Student to Scientist

This experience has changed how I view research. It is no longer just something I study — it is something I actively contribute to.

It has also strengthened my interest in pharmaceutical research, showing me how lab innovation can eventually translate into real treatments for patients.

Final Thoughts

Research may begin in the lab, but its impact reaches far beyond it.

Every measurement, every experiment, and every challenge faced is part of a journey toward improving health and saving lives. For students like me, it is a reminder that what we do today in the lab could shape the treatments of tomorrow.

Written by Abdulrahman Alowaihan

IACR 2026: Science, Communication, and Impact 

 I recently had the opportunity to attend and present my research at the Irish Association for Cancer Research Conference 2026 in Galway. This year was particularly special for me, as I was selected as one of six early-career researchers to take part in the Prof. Patrick G. Johnston Award for Excellence in Cancer Research Outreach. 

This award recognises researchers who can communicate their work clearly to a public audience. Those selected are chosen based on their lay abstracts and take part in a patient communication workshop ahead of the conference. As part of this, I had the opportunity to work closely with patient advocates and cancer survivors, which was an incredibly valuable experience. It challenged me to think beyond science and focus on how to make my research meaningful, accessible, and relevant to the people it ultimately aims to help. 

My presentation at IACR 2026

During the conference, I presented my research as part of this award session, delivering a lay presentation to an audience made up of scientists, patients, and members of the public. 

My research focuses on developing 3D lung models to better understand cancer behaviour and explore new ways to target lung cancer using mRNA-based approaches. Being able to present this work in a way that resonated with a non-scientific audience was both challenging and rewarding. 

Overall, the conference was an inspiring experience. It reinforced the importance of communication in cancer research and reminded me that behind every project are patients and families who are directly impacted by the work we do. 

Until next time,  

Written by Eve O’Donoghue

Hiya! I’m Nicole 

Hi everyone! I am Nicole, and I recently joined Dr. Olga Piskarvera’s team as a research intern for 8 months. I am 21 years old, and I am currently in my 3rd year of my degree in Advanced Therapeutic Technologies at RCSI. It’s essentially a fusion of biomedical science and biotechnology with emphasis on bioinformatics! 

Mochi

 I have always loved science and dreamt of working in a lab since I was a little, so being able to explore both bioinformatics and lab work is an exciting way to explore my curiosity and creativity. I was quite nervous starting out because I didn’t know what to expect, especially in the lab, as I was afraid of making mistakes. However, I am slowly learning and becoming more confident each day! 

Vietnamese beef pho

A few facts about me: I love animals, especially cats, and, of course, I have a cat myself! Her name is Mochi, and she’s a Scottish fold; she has been my little companion since I was 15. One of my favourite foods is Vietnamese beef pho (Aobaba on Capel Street is my go-to!). I also enjoy reading in my spare time. Two of my favourite books are Homeseeking by Karissa Chen and The Hot Zone by Richard Preston. 

I am looking forward to everything I’ll learning during my time with this team! 😊

Written by Nicole Guo

Student placements

Hi everyone!

My name is Maryam Almotawaa, and I’m a 4th-year pharmacy student.

I am working on research to identify a promising tumour-associated antigen for immunotherapy. I used the R2 platform to review datasets, including neuroblastoma and non-small cell lung cancer. I spent some time in the lab observing Lin and Eve working on a Western blot for GPC2, a promising neuroblastoma and non-small cell lung cancer antigen. I was involved in a small part of a Western blot experiment in which I washed the secondary antibody. Even though it wasn’t a big task, it made me realise that even small steps matter and can affect the final result.

Outside my academic life, I really enjoy spending quality time with my friends, whether that’s catching up over coffee or exploring new food spots around Dublin. I also value having time to unwind and recharge, especially after busy academic periods, as it helps me maintain a good balance between my studies and personal life.

All vials contain specific solutions that help confirm protein expression adsorbed onto the PVDF membrane.

Written by Maryam Almotawaa

Rabia Saleem: My Portuguese Journey

I’m in my third year of a PhD at RCSI and recently completed an RCSI-funded secondment. Reflecting on it, it has been one of my most enjoyable and valuable experiences so far. Coming back to Ireland after the secondment feels great. I’m feeling refreshed and eager to dive back into my work.

I spent my placement at the University of Lisbon’s Department of Pharmacy, working in Prof. Helena Florindo’s lab. Everyone was super welcoming, which made it easy to settle in and get started without any stress.

Most of my time in the lab was spent preparing biodegradable nanoparticles using a peptide from my project. I also got to run some ex vivo experiments and even joined in on in vivo work under supervision, a completely new and really exciting experience for me. The best part was seeing some promising results come through, which was really encouraging.

Outside the lab, Lisbon was just a lovely place to spend time. I picked up a little Portuguese, enjoyed the sunshine, and appreciated the relaxed pace.

Now that I’m back, I’m excited to finish up the last bits of my project and build on what I learned during the secondment. Overall, it was an amazing experience, both for my research and personally.

Written by Rabia Saleem, the IRC PhD student

Two New-Minted PhD in 2025!

What a year – two young and talented postgraduate students have been minted with a Doctor of Philosophy Degree in September and December of 2025. They are Dr Lin Ma and Dr Ronja Struck. Hard work and dedication are the cornerstones of this challenging but rewarding journey.

They sailed through scattered showers and sunny spells, gale winds and stormy snow with sunshine developing elsewhere, turning chilly under clear skies on some days with temperatures below/above zero. The full spectrum of emotions and hard work was spiced up by the uncertainty of COVID-19 restrictions. Well done to Ronja and Lin!

My greatest thanks to Lin’s examiners Prof Sue Burchill (University of Leeds, UK),  Dr Joan Ní Gabhann-Dromgoole  (RCSI, Ireland) and the independent chair Prof Kevin McGuigan (RCSI, Ireland)!!

My greatest thanks to Ronja’s examiners, Prof Martina Rauner (Dresden University, Germany), Prof Fabio Quondamatteo (RCSI, Ireland) and the independent chair Dr Inmar Schoen (RCSI, Ireland)!!

This work would not be possible without the generous support from the Irish Research Council (Research Ireland) and the Conor Foley Neuroblastoma Cancer Research Foundation to Ronja, and from the RCSI-Soochow University StAR International PhD Programme to Lin.

How cancer cells communicate?

Hot off the press! The study carried out by Thomas Frawley during his PhD has just been published in Journal of Personalized Medicine.

Cancer that is resistant to treatment is a big challenge because it often leads to lower survival rates. Tumour cells release small extracellular vesicles, which can influence other cells in the body by carrying various proteins. The study focused on understanding what proteins are in these particles from resistant and sensitive cancer cells and how they affect non-cancerous cells, like those involved in forming blood vessels. Our study discovered that these packages from resistant cancer cells contain special proteins involved in how cells produce and use energy. These findings suggest that these proteins could be used as markers to monitor disease progression or treatment response, using less invasive methods such as blood tests.

A schematic summary of Frawley’s study, also known as a graphical abstract. J. Pers. Med. 2025, 15(12), 584; https://doi.org/10.3390/jpm15120584 (registering DOI)

Understanding how resistant cancer cells influence their surroundings could lead to new ways of diagnosing and treating high-risk neuroblastoma. Detecting these proteins through blood tests could help personalise treatment strategies, making them more effective without the need for invasive procedures. This research opens the door to using tiny particles from blood to better understand how cancer progresses and responds to therapy.​

I’m Pierluca!

Good afternoon, readers! Pierluca here, writing to you as one of the newest members of this incredible team. For those who haven’t met me yet, I’m a PhD student joining the RCSI family for the next three years.  

My story starts in Brindisi, a charming harbor town in southeastern Italy. From there, my academic journey took me to the Netherlands.  During my two research projects, I explored how high-fat diets impact liver metabolism and investigated ways to prevent metabolic reprogramming and cell death.  

Now, I’m bringing that curiosity to RCSI, where my focus is shifting to something even more complex: cancer metastasis. In the lab, I’ll research how neuroblastoma invades the brain to form metastases. Using 3D bioprinting and scaffold models, I’ll grow Neuroblastoma Kelly and Kelly-cis cells to observe how they infiltrate brain-like structures and hijack the immune system.  

Science is intense, so balance is key! When I’m not in the lab, you’ll find me Hiking when the sun is shining or Playing cards in a cozy pub when the rain pours. Cooking with friends is a great way to spend some relaxing time at home and when I am alone, I enjoy a good book (currently reading The Master and Margarita, highly recommend!). 

Stay tuned for more about me and my research! 

Written by Pierluca Cancellieri, Mac4Me PhD student

From Bench to Belfast 

Thanks to the Breakthrough Cancer Research Education and Travel Award, I had the chance to attend the Irish Association for Cancer Research (IACR) Conference 2025 in Belfast—an insightful and rewarding experience. 

I presented a poster on my research into the regulation of GPC2 in lung adenocarcinoma and squamous cell carcinoma. The poster session was a great opportunity to share my work, receive constructive feedback, and speak with researchers working on similar topics. These conversations have given me new ideas to take back to the lab. 

One of the most valuable sessions for me was the “PPI in Action” workshop, which focused on making patient and public involvement more inclusive. It introduced me to new perspectives on how researchers can engage directly with patients and the public. I left inspired to explore starting a PPI group for lung cancer at my own institution. 

Another highlight was the Patrick Johnston Award session, where early-career researchers presented their work in lay terms. It was a strong reminder of the importance of clear, accessible science communication. 

Beyond the conference, I enjoyed exploring Belfast—Victoria Square offered amazing views, and the architecture around City Hall was well worth the visit. 

Overall, the conference was a great opportunity to connect, learn, and reflect. I’m very grateful to Breakthrough Cancer Research for supporting my attendance and look forward to applying what I learned to my research going forward. 

Written by Eve O’Donoghue

My Chinese leg of the PhD journey

Hi, it’s Lin again!  

Welcome to my first blog post of the year—and the first in two and a half years. You might be wondering what I’ve been up to during that time. Let me catch you up! 

I’m currently pursuing a joint Ph.D. programme between the Royal College of Surgeons in Ireland (RCSI) and Soochow University (SU) in China. For the past two years, I’ve been based at SU. My project has offered me a unique opportunity to experience and compare research environments across two countries, each with its own strengths, workflows, and lab cultures. 

So, what is it like working in a Chinese research lab? 

Beyond the routine experimental tasks, one of the standout features of this lab is its comprehensive capacity for conducting animal studies—all performed in strict accordance with ethical guidelines. I’ve had the opportunity to observe and work with a wide variety of laboratory animals, including mice and rabbits. Interestingly, depending on the specific needs of a project, researchers can even select animals based on precise characteristics, such as coat colour or genetic background. 

In addition to lab work, the research environment here provides frequent opportunities to attend academic conferences and participate in scholarly exchanges. These events are invaluable for sharing findings, building professional networks, and exploring future collaborations—both nationally and internationally.

Outside the lab, work-life balance is also encouraged. My colleagues and I often take part in group outdoor activities like cycling around the nearby lake, camping, and barbecuing. These shared experiences not only bring joy to our daily lives but also help foster stronger team spirit and collaboration.

And the good news is – I have just submitted my PhD thesis! Onwards and Upwards!

Written by Lin Ma