This summer I worked under Dr Piskareva supervision in the remote research program. My original plans for a lab experience were put down by COVID. My ultimate goal was to write the review article on the potential uses of retinoic acid in neuroblastoma research.
Before starting the project, I didn’t have any specific expectations. While I always had fun picking the primary articles apart and summarising the gathered data during my undergrad and med school, I didn’t believe that this experience would be the special one. And I kept thinking so as I was collecting the information from the numerous data on cell cultures. And as I was looking at the mice models studies. And clinical trials.
Then I started to write my introduction, and so researched the information on the neuroblastoma prognosis, contemporary treatment protocol and outcomes. And suddenly I saw my project in the new light. I was used to regarding the clinical trials outcomes as simple statistics, but this time no desensitization could shield me. Yes, 60% of the patients in the high-risk group die in 5 years after diagnosis, and yes, 90% of those patients are children less than 5 years old. And there is nothing that we could currently do to save those children.
On the other hand, this realisation brought meaning to my work. This time, I was not doing a PubMed search to get a good mark or CV reference. Instead, I was looking for the possible treatment of the disease. My review on the current knowledge about retinoic acid will let the other primary researchers target the most promising drug for future experiments and, eventually, create a novel and effective therapy to help those children.
And isn’t it what we are all striving for in medical research?