What is a must-see in Ireland? Right: visit Guinness brewery at St. James’s Gate and have a pint of right Guinness. It is one of the most recognised and famous beer brands. Rumours say Dublin is the only place where Guinness tastes Guinness. Traditions, traditions and traditions. Though the one we like most Guinness Draught is a relatively new addition – it was introduced almost 200 years after the brewery establishment in 1759 by Arthur Guinness.
So, what if you like tastes ‘outside the box’? Then Guinness brewery in Baltimore is for you. Respecting the Father, they do completely different stuff. Imagine, 16 different tastes, including the one we know! You can have a guided tour of the brewery, hear the great story and do a beer tasting. Have you tried one? Not, the one in the pub or with the friends at BBQ. It is a special way to feel the bouquet of flavours and taste the difference. There is a difference between the beer drunk straight from the bottle and from the glass. Because you can smell it as simple as that.
During our guided tour, we rambled inside the experimental brewery, learn the basics of beer production, tasted 4 types of beer: Guinness Blonde, Oatmeal Pale Ale, Guinness Draught and Guinness Milk Stout. Three were absolutely new for me. I liked Oatmeal Pale Ale, found Milk Stout a bit dessert style, Blonde – too citrusy. Do not forget, another 12 you can taste at the bar in a special set! However, to enjoy the most you have to bring your friends. All is much better with the right company!
Can you control the time? I can’t and know none who can. It flies, when things around you work out, and drags on when not. The time flies for me here in Baltimore. It feels so intense sometimes and then slightly slows down. I take pictures almost of everything: the path’s signposts when rambling in the network of Johns Hopkins Buildings, the first frosty morning, joyful deer at the backyard of my host family house, outdated clothes in the shop…
In the past, I had a similar journey to Ireland. It was 3 months research placement during my PhD. Did I like it – oh, yes I did! I travelled a lot, felt romantic and changed my life on my return home. But I did not run a diary or tag my way on Facebook. I have learnt the lesson: do it even more intense as you can’t travel back in time and write down your experience. It may be funny or educational to read in a couple of years! I become addicted to it though not always have time to do it.
I like the people who I am working with. They are a fantastic bunch of self-motivators and open-minded personalities. They are workaholics either naturally like me or because of the exciting projects they do like I do. Who knows, but very likely because of both. Isn’t it a dream to have an exciting project and great people around you? The luck like this gives you wings.
The host family – is my other great luck! This luck was crafted as a parallel story when none knew how the Fulbright application and an American enthusiast learning Russian may intersect. You would not believe, but parallel lines can be non-parallel sometimes! His journey to my home city in Russia paved the way to the opportunity to stay at his aunt’s house.
Every day 50 min drive to and from Hopkins opens up the other side of the local lifestyle and infrastructure. What are the rush hours? How many drivers are signalling before taking a turn? How do they call the shopping trolley? How parking system works?
Experiencing life as an American working in Baltimore.
It is also the unofficial end of summer when many people arrange family gatherings or holidays. So, did our lab. We were all invited to our boss’ house to have a BBQ and chit-chat. As you may expect almost everyone in the lab has a multicultural background which is very proud of. You are in America, babe! I am not an exception. A proud Irish-Russian.
Everyone took advantage of and benefited from that mix. We had Mexican, Argentinian, French, Irish, Jewish, Ethiopian and American Indiana, Idaho, Florida, Maryland bites. Juicy steaks (raw, medium and well done) and burgers grilled by the host Andy were delicious. Have to admit that meat was tastier than I used to buy in Ireland. Should probably look for a new butcher when I come back!
What did surprise me the most? I have been thinking about it on the way home… None of 15 guests did check their mobile or take a pic of food/selfie during that time! Though everyone had this thing in the pocket. We were chatting and laughing. Maybe it is just that people… Fantastic company and a great day out.
When I look back at the end of July, I am always surprised how quickly 8 summer weeks passed by. Summer students usually come very shy and uncertain and then they are flying through many complicated research terms and techniques. We help them to learn and they pay back by fantastic enthusiasm, commitment, and hard work. This summer was the same!
One of our experiences was donut’s tasting. We tasted donuts from Boston Donuts, the Rolling Donut, Boomerang Donuts and Krust Bakery. Many shapes, textures, and tastes. Krust Bakery did our favourites. 🙂
Appeared in today’s Irish Times. Lovely crafted by Dr. Vanesa Martinez
Although the discovery could be applicable in principle to any a solid tumour, Dr Piskareva’s target is neuroblastoma, a relatively common child cancer which affects a specific type of nerve cells in unborn children. “It’s quite aggressive and unfortunately there are many children who have metastasis when they are diagnosed, and this is the most challenging group to treat.”
The researcher’s path includes days when you feel so low because your grant or paper was rejected or even both within a very short time frame. It happened to me a couple of weeks ago. At this point, I felt helpless sarcastic and non-motivative reading reviewer’s comments. One reviewer mixed up neuroblastoma with a brain tumour, so their comments were not relevant. Another just found no time to read through, the sentence was very short – ‘not a priority or interest‘. One more went to their area of expertise asking to fulfil it rather than comment on the actual focus of the study. Such comments are so common that any submission of results or a proposal could be considered as a draw. It has been neither my first time not the last. More to come.
Continuing the fundraising theme, I would like to introduce The Conor Foley Neuroblastoma Cancer Research Foundation. It is founded by the family aiming to raise awareness and funding for neuroblastoma – one of the most aggressive childhood cancer. This charity is being driven by parents who lost their son to neuroblastoma. They want to fill this gap as well as bring attention to the lack of funding for childhood cancer research.
Their son Conor was diagnosed with neuroblastoma at the age of four. He was a teenager when he relapsed. He had been 10 years cancer-free. After all possible treatments, neuroblastoma took over.
His mom Margaret says:
“We always dealt with Conor’s illness privately. There were no Facebook pages tracking Conor’s progress. The day we launched the website for Conor’s charity was very emotional for me. I feel like he is out there now in the big world now with his charity. He will never get to do the things that most 18-year-olds do. He won’t go inter-railing in the summer, he’ll never go bungee jumping off some bridge, but I feel that he’s part of the world, doing something good for other children and their families. We valued our time with Conor so much, we want to help researchers who will give families, even more time, more options, perhaps even a cure for their children when they get the same awful news that we did. I think he would approve of that.”
It is very quiet in the lab this month. No troubleshooting, no more long working hours, endless repetition of experiments, smiles and upsets… Almost all students completed their projects, submitted their works for grading and graduated. The last student is finishing at the end of August.
Time to focus on the collected data, reading literature, writing papers and new grants.
The research is a long-term investment. It is always built up on the work of the predecessors. Keep research running is crucial to make the dreams come true. Dreams for better treatment options and quality of life.
Thank you to everyone involved in raising funds for CMRF!
To understand the world around us, we have to do be curious and do “blue sky or curiosity-driven” research. It is a long shot, but this type of research can lead to practical applications down the road. One of the most recent examples is a drug Vismodegib (Erivedse) to treat basal cell carcinoma (the most common type of skin cancer) approved by the FDA in 2012. This drug targets genes of a hedgehog-associated signalling pathway. Defects in this pathway were found to drive many cases of skin cancer. But, how this relationship was found? Blue sky research!
Researchers studied hedgehog signalling in fruit flies and mice. One of the researchers had a strong interest in a fruit fly gene called hedgehog. If this gene is defective, then fly embryos look stubby and hairy aka a hedgehog. Further research brought more interesting facts and relationships leading to the identification of a drug that can stop the function of this faulty gene. Decades later with the advancement of genome sequencing, the defect in hedgehog signalling pathway genes was identified in patients with locally advanced and metastatic basal cell carcinoma.
What would happen if there were no research in fruit flies and mice? There would have been no rationale to create a drug like Vismodegib!
The best discovery research is unrestricted. It is driven by intellectual curiosity and conceptual advancement. More such curiosity- driven research is needed. For every medical breakthrough, for every Vismodegib, there were hundreds of blind alleys and failed ideas.
The research is a long-term investment. This contradicts to the short-term life of the politicians and governments who give the money. They do not take the risks. So, the discovery research becomes critically underfunded.
Fundraising creates opportunities for blue sky research and developing cancer treatments.
Thank you all who support cancer research charities!