Women in Science: Madame Curie

Women have made significant contributions to the field of science throughout history, but they have often faced gender-based barriers and discrimination. Despite the challenges, several pioneering women made significant contributions to various scientific fields. Marie Curie, for example, conducted ground-breaking research in radioactivity and was the first person (and remains the only woman) to win Nobel Prizes in two different scientific disciplines (physics and chemistry). In 1903, she received the Nobel Prize in Physics along with Pierre Curie and Henri Becquerel for their work on radioactivity. Later, in 1911, she received the Nobel Prize in Chemistry for her contributions to the understanding of radium and polonium. These discoveries had a profound impact on the understanding of atomic and nuclear physics and laid the foundation for numerous scientific and medical advancements. They led the development of X-ray machines for medical diagnosis and the development of cancer treatment through radiation therapy (NobelPrize.org, 2023).

As a woman in the 20th Century, Madame Curie too faced early struggles with financial and gender-related challenges in her pursuit of education. She had to work hard as a governess and in other low-paying jobs to support her sister’s education before she could attend University. Her struggles continued into her research, where she first published her early scientific work under the pseudonym “Pierre Curie” to avoid gender bias and prejudice. This allowed her to have her work taken more seriously. However, despite her struggles to receive an education, in 1906, Marie Curie herself became the first Female Professor at the University of Paris (MarieCurie.org, 2023)

Marie Curie not alone made epic contributions to science, she was also involved in war efforts. During World War I, Marie Curie developed mobile radiography units, or “Little Curies,” to provide X-ray services to wounded soldiers. She and her daughter, Irène, operated these units on the front lines. She also served as the director of the Red Cross Radiology Service and trained nurses and doctors in radiography (Davis, 2016).

Madame Curie passed away on July 4, 1934, in Sallanches, France, but her legacy in the world of science endures. Marie Curie’s personal cookbook and other belongings are still radioactive and are stored in lead-lined boxes at the National Library in Paris. They will remain radioactive for thousands of years. The Musée Curie (Curie Museum) is a museum located in Marie Curie’s former laboratory at the Institut du Radium in Paris. It showcases her personal artefacts, laboratory equipment, and documents related to her research on radioactivity. If you are holidaying in Paris, you can take an hour and explore the laboratory space and learn about the scientific achievements of Marie Curie and her husband, Pierre Curie. For me, Marie Curie’s dedication to research, numerous contributions to the field of radioactivity, and her status as a trailblazing woman in science is inspiring. I hope her legacy will continue to inspire generations of scientists and serve as a testament to the power of scientific curiosity and perseverance.

Fun fact: Radium became a popular element in various consumer products during the early 20th century. It was added to items like toothpaste, face creams, and even drinks, all of which claimed to provide health benefits. Marie Curie herself endorsed some of these products before the health risks of radiation exposure were well understood (Santos, 2021).

Written by Ciara Gallagher

Reading:

DAVIS, A. 2016. How Marie Curie Helped Save a Million Soldiers During World War I The radiology pioneer developed and operated mobile X-ray units to treat the injured. Available: https://spectrum.ieee.org/how-marie-curie-helped-save-a-million-soldiers-during-world-war-i [Accessed 2023].

MARIECURIE.ORG. 2023. Marie Curie the scientist [Online]. Available: https://www.mariecurie.org.uk/who/our-history/marie-curie-the-scientist#:~:text=Born%20Maria%20Sk%C5%82odowska,She%20never%20lost%20this%20passion. [Accessed].

NOBELPRIZE.ORG. 2023. Marie Curie [Online].  [Accessed 24/10/23 2023].

SANTOS, L. J. 2021. “A Revolutionary Beauty Secret!” On the Rise and Fall of Radium in the Beauty Industry. LitHub.

Childhood Cancer Awareness Month 2023

Every September, we celebrate Childhood Cancer Awareness Month. This is a great opportunity to raise awareness about childhood cancer. Unfortunately, kids get cancer, too. While much research has been done to understand how cancer develops in adults, we still know very little about what exactly leads to cancer in children.

We are the Cancer BioEngineering Group led by Dr Olga Piskareva at the RCSI University of Medicine and Health Sciences. Our research focuses on neuroblastoma, an aggressive childhood cancer of immature nerves. The group has 7 PhD students developing research projects around neuroblastoma biology. One postgraduate student successfully defended her work and was awarded a PhD last month.

We are a dynamic group proud to be engaged in research, science communication and patient involvement. We do that through different initiatives. Throughout September, we will share many of them and invite you to keep following us on social media. 

Team 2023

Our projects address topics related to neuroblastoma microenvironment, cell interactions, tumour resistance and the development of new therapies. To do that, we use 3D in vitro models, identify immunotherapeutic targets and evaluate extracellular vesicles.  

We are always happy to answer questions and interact with the public. Follow us on our social media channels and read our blog to learn more about us and our research.  

We are running a fundraising event, “A knit-a-thon,” on the 19th of September. Stay tuned!

Thanks for reading, and we go ahead with neuroblastoma research! 

September is Childhood Cancer Awareness Month

We celebrate Childhood Cancer Awareness Month every September. This is our chance to talk about this cancer, the patients and their families and what can be done to make a change.

Together with Prof Richard Arnett we asked a question – how intense is communication about neuroblastoma/childhood cancer on Twitter. There were 52126 neuroblastoma tweets in 69 days. Is it a big number?

#neuroblastoma on Twitter

Yellow dotes represent tweets. The intensity of yellow reflects the number of tweets per account. Many of them formed isolated communities with no connections. A few reach out. And this is very sad, it means that these communities do not interact with each other.

Communities have to come together then they will be heard. The Childhood Cancer Awareness months is a great opportunity to do it.

SFI Technology Innovation Development Award

An interesting idea or research question is always motivational. But it is a sketch till you get means to answer them. We, scientists, have to shape them into a proposal showing that we know limitations and have plans B & C if things go differently to planned. Then we apply for funding here and there… and many many times. The number of rejections makes us stronger – I hope. But one day, the idea may hit it right. So, it has happened to me recently and this SFI Award brings so needed fuel to study neuroblastoma.

The development and approval of new oncology drugs are very slow processes. This is mainly due to the big differences in the physiology of cancer cells grown on plastic and in the native microenvironment. Tissue engineering of tumour systems has a great potential to bridge this gap. This Award will help to advance our 3D tissue-engineered of neuroblastoma, that can be used in testing new drugs and new combinations of existing drugs.

Neuroblastoma cells grown in 3D

In particular, we will adapt the 3D model to screen different immunotherapies. This treatment option is very attractive both for adults and children because of its specificity and reduced side effects compared to chemotherapy, the current standard of care.

This Award will help my team to get a better understanding how neuroblastoma cells interact with the body environment, particularly with the immune system and how we can use the knowledge to develop new treatments and improve the patient outlook.

International Childhood Cancer Awareness Day – February 15th 2019

International Childhood Cancer Day (ICCD) was founded in 2002 by Childhood Cancer International (CCI). Each year on February 15th we unite together to recognise childhood cancer as a national and global child health priority & to raise support, funding and awareness of this devastating desiease.

This year we team up with Amorino to run Hot Chocolate Morning.  Please come along! All proceeds go to CMRF/NCRC and CFNCRF.

If you can’t join us, you can simply follow the link and donate ‘a cup of coffee/hot chocolate’ to CMRF Crumlin, the Conor Foley Neuroblastoma Research Foundation & Childhood Cancer Foundation


Facebook Collection

I have a nice collection of pictures related to our lab activities or research, not all of them were posted here. Hope, that Facebook could provide an additional nice platform to store and share them. I am grouping them by theme in an album and link with a relevant blog post.

Let see how it would work!

 

A new, three-dimensional approach to cancer research

Appeared in today’s Irish Times. Lovely crafted by Dr. Vanesa Martinez

Although the discovery could be applicable in principle to any a solid tumour, Dr Piskareva’s target is neuroblastoma, a relatively common child cancer which affects a specific type of nerve cells in unborn children. “It’s quite aggressive and unfortunately there are many children who have metastasis when they are diagnosed, and this is the most challenging group to treat.”

Irish Times, 31 May 2018

https://www.irishtimes.com/news/science/a-new-three-dimensional-approach-to-cancer-research-1.3505347

Networks of Galaxies

Some researchers look into possibilities to predict real “me” by analysing what and how was said on social media.

This network of galaxies is a new project to get insights on how and where childhood cancer is placed on social media. It is a collaborative project with Prof Richard Arnett. It is already very exciting and more to come!