What a great start for 2020! Our long-lasting and productive collaboration with our colleagues from Tissue-Engineering Research Group Brough to live an important overview of the preclinical models for neuroblastoma. We particularly focused on the 3D in vitro models available.
During this exercise of searching and reading research papers, we found that researchers in neuroblastoma are looking for alternatives of traditional 2D culture. It is may be slow at the moment but the interest is there.
3D neuroblastoma models worked well in both validating known chemotherapies and screening new. The concepts and materials that were initially developed for bone or tissue regeneration can be used to a miniature model of neuroblastoma.
3D tissue-engineered models can accelerate drug discovery and development, reducing the use of animals in preclinical studies.